Rethinking Clinical Trials: A Living Textbook of Pragmatic Clinical Trials
Welcome to the Living Textbook of pragmatic clinical trials, a collection of knowledge from the NIH Pragmatic Trials Collaboratory. Pragmatic clinical trials present an opportunity to efficiently generate high-quality evidence to inform medical decision-making. However, these trials pose different challenges than traditional clinical trials. The Living Textbook reflects a collection of special considerations and best practices in the design, conduct, and reporting of pragmatic clinical trials.
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What is the
NIH Pragmatic Trials Collaboratory?
What is a
pragmatic clinical trial?
Training Resources
Featured
Registration Opens for Pragmatic Trials Workshop at SCT 45th Annual Meeting
The NIH Pragmatic Trials Collaboratory will offer a preconference workshop at the 45th Annual Meeting of the Society for Clinical Trials in Boston titled “Patient-Centered Research in Real-World Settings: Essentials of Embedded Pragmatic Clinical Trials.” Registration for the workshop is now open.
NIH Pragmatic Trials Collaboratory Launches New Online Training Resources
Check out the new training resources page, featuring a video library, learning modules, and workshop archives. Take a tour of the enhanced training resources webpages we built to help researchers learn about pragmatic trials.
NIH COLLABORATORY TRIALS
Pragmatic clinical trials that address questions of major public health importance and provide proof of concept for innovative pragmatic research designs.
CORES
Working groups that support the conduct of NIH Collaboratory Trials and generate guidance addressing implementation challenges.
DISTRIBUTED RESEARCH NETWORK
Network enabling investigators to collaborate in the use of electronic health data while safeguarding protected health information.
Upcoming Learning Opportunities
Grand Rounds May 17, 2024: CardioHealth Alliance: A Platform to Improve Care (Ken Mahaffey, MD; Nishant Shah, MD; Neha Pagidipati, MD, MPH)
May 17 @ 1:00 pm - 2:00 pmGrand Rounds May 31, 2024: The INSPIRE Abdominal & Skin/Soft Tissue Infection Trials: INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients (Shruti Gohil, MD, MPH)
May 31 @ 1:00 pm - 2:00 pm
NEWS
- May 1, 2024: PKIDS Pragmatic Trial to Be Featured in PCT Grand RoundsIn this Friday’s PCT Grand Rounds, Gregory Tasian of the Children’s Hospital of Philadelphia will present “Comparative Effectiveness of Kidney Stone Surgery in Pediatric Patients: The PKIDS Trial.” The Grand Rounds ...
- April 24, 2024: Developments in Waivers and Alterations of Informed Consent in Minimal-Risk Research, in This Week’s PCT Grand RoundsIn this Friday’s PCT Grand Rounds, Lauren Milner of the US Food and Drug Administration (FDA) and Jonathan Casey and Matthew Semler of Vanderbilt University will present “Waiver or Alteration ...
- April 23, 2024: Younger, Uninsured Patients Among Those at Greatest Risk for Missing Follow-up Assessments in Trauma ResearchIn an analysis of data from the TSOS study, younger patients and patients who were publicly insured or uninsured were among several subgroups of patients who were at significant risk ...